General objective of this article is to explain Polycythemia Vera. Polycythemia Vera is vaused by the over production connected with red blood cells. Nonetheless, it is also combined with an increase in the quantity of white blood cells and platelets likewise. The occurrence of this rare disease can be found more in men than women which is more common in affected individuals who are above the age of 40. The roots of this bone marrow disorder are already tracked to gene mutation called JAK2V617F though the basis of this mutation has not yet been discovered. Here also briefly explain Symptoms and Diagnosis system of Polycythemia Vera.